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Related Experiment Videos

[CD30 positive pilotropic lymphoma].

C Trémeau-Martinage1, B Gorguet, L Lamant

  • 1Service de Dermatologie, Allergologie et Vénéréologie, CHU de Purpan, Toulouse.

Annales De Dermatologie Et De Venereologie
|August 6, 1999
PubMed
Summary
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This case study details a rare, aggressive cutaneous CD30-positive lymphoma with follicular tropism and Sézary cells, leading to a rapid fatal outcome. It highlights the potential transformation of Sézary syndrome into this aggressive lymphoma subtype.

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Presents an unusual case of cutaneous CD30-positive lymphoma.
  • Highlights pilar tropism and circulating Sézary cells.
  • Notes a rapidly fatal clinical course.

Observation:

  • A 78-year-old man exhibited facial erythema, pruritic eruption with follicular papules, and lymphadenopathy.
  • Blood smears revealed significant numbers of circulating Sézary cells.
  • Skin biopsy showed perifollicular lymphoid infiltration, with tumor cells expressing CD2, CD3, CD4, and CD30.

Findings:

  • Histopathology and immunohistochemistry confirmed CD30-positive lymphoma with pilar involvement.
  • Bone marrow smears indicated lymphomatous infiltration.
  • Genetic analysis detected a T-cell clone in blood and bone marrow.

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Implications:

  • Suggests transformation of Sézary syndrome into CD30-positive large cell lymphoma.
  • The pilotropic eruption and rapid progression are key diagnostic indicators.
  • This case expands understanding of rare lymphoma presentations and transformations.