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Updated: Aug 16, 2026
09:31
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
[Pleural malignant mesothelioma complicated by multiple myeloma]
K Kuribayashi1, D Ihaku, H Nakamura
15th Department of Internal Medicine, Hyogo College of Medicine.
Summary
A patient initially diagnosed with multiple myeloma due to pleural effusion and thickening was posthumously found to have malignant mesothelioma. This case highlights diagnostic challenges in pleural diseases.
Area of Science:
- Oncology
- Pulmonology
- Pathology
Background:
- Pleural effusion and thickening can present with various underlying causes.
- Distinguishing between neoplastic and inflammatory pleural conditions is critical for patient management.
Observation:
- A 79-year-old female presented with dyspnea, left pleural effusion, and diffuse pleural thickening on imaging.
- Initial investigations including blood tests and bone marrow biopsy suggested multiple myeloma.
Findings:
- Despite initial suspicion of multiple myeloma causing pleural lesions, autopsy revealed malignant mesothelioma of the pleura.
- Histological and immunohistological studies confirmed the mesothelioma diagnosis, revising the initial assessment.
Implications:
- This case underscores the importance of comprehensive histopathological evaluation for accurate diagnosis of pleural abnormalities.
- Misdiagnosis can occur, emphasizing the need for advanced diagnostic techniques in complex cases.
- Understanding the differential diagnosis of pleural disease is crucial for oncologists and pulmonologists.
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