Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect-site modelling of propofol using auditory evoked potentials.

M White1, M J Schenkels, F H Engbers

  • 1Department of Anaesthesiology, Leiden University Medical Centre, The Netherlands.

British Journal of Anaesthesia
|August 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nikolay Ivanovich Pirogov (1810-1881): Anatomical research to develop surgery.

Clinical anatomy (New York, N.Y.)·2019
Same author

Nikolay Ivanovich Pirogov: a surgeon's contribution to military and civilian anaesthesia.

Anaesthesia·2014
Same author

Pharmacokinetic models for propofol: defining and illuminating the devil in the detail.

British journal of anaesthesia·2010
Same author

Inhalation anaesthesia: from diethyl ether to xenon.

Handbook of experimental pharmacology·2008
Same author

Drugs and haemostasis.

Current opinion in anaesthesiology·2006
Same author

Sedation for endoscopy.

Current opinion in anaesthesiology·2006

This study monitored central nervous system effects using auditory evoked potentials (AEP) during propofol anesthesia. Modeling successfully linked drug concentration to AEP effects, aiding in understanding anesthesia depth and recovery.

Area of Science:

  • Anesthesiology
  • Pharmacokinetics and Pharmacodynamics
  • Neurophysiology

Background:

  • Auditory evoked potentials (AEP) are sensitive indicators of central nervous system (CNS) function.
  • Propofol is a widely used intravenous anesthetic agent, and understanding its pharmacokinetic/pharmacodynamic (PK/PD) relationship is crucial for safe administration.
  • Monitoring CNS effects during anesthesia induction and recovery is essential for optimizing patient care.

Purpose of the Study:

  • To monitor central nervous system (CNS) effects during propofol anesthesia using auditory evoked potentials (AEP).
  • To successfully calculate the pharmacokinetic parameter keo, linking drug concentration to AEP effects.
  • To determine the effect-site concentration (Ce50) associated with 50% AEP effect and estimate recovery concentrations.

Main Methods:

Related Experiment Videos

  • Auditory evoked potentials (AEP) were recorded in 22 healthy male patients undergoing anesthesia induced by propofol infusion (30 mg kg-1 h-1).
  • Non-parametric and parametric modeling techniques were employed to calculate the keo parameter, which describes the link between drug concentration and effect.
  • Effect-site concentration (Ce50) for 50% AEP effect and recovery concentrations were estimated using the calculated keo values.

Main Results:

  • The parameter keo, linking pharmacokinetics and pharmacodynamics, was successfully calculated in 15 patients, with a mean non-parametric value of 0.2 min-1 (range 0.1-0.36).
  • The population effect-site concentration (Ce50) for 50% AEP effect was estimated at 2.08 µg/mL (95% CI: 1.7-2.45 µg/mL).
  • No significant differences were found between keo values derived from non-parametric and parametric modeling. During recovery, 50% of patients showed signs of waking at an effect-site concentration of 2.28 µg/mL.

Conclusions:

  • Non-parametric and parametric modeling techniques can successfully link propofol pharmacokinetics to pharmacodynamics via the keo parameter.
  • The calculated Ce50 provides a valuable reference for the depth of anesthesia based on AEP.
  • The estimated effect-site concentration at recovery aids in understanding and managing patient emergence from propofol anesthesia.