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Risk factors for acquisition of gentamicin-resistant enterococcal infection: a case-controlled study

M Viagappan1, R E Holliman

  • 1Department of Medical Microbiology, St George's Hospital & Medical School, London, UK.

Postgraduate Medical Journal
|August 6, 1999
PubMed

Insights

High-level gentamicin-resistant enterococci (HLG શ્રે) infections pose treatment challenges. Prior prolonged antibiotic use, multiple antibiotic exposure, and urinary catheterization are key risk factors for HLG શ્રે acquisition.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Hospital Epidemiology

Background:

  • High-level gentamicin-resistant enterococci (HLG શ્રે) complicate patient treatment due to loss of synergistic antibiotic effects.
  • Understanding risk factors for HLG શ્રે acquisition is crucial for effective infection control.

Purpose of the Study:

  • To identify key risk factors associated with the acquisition of high-level gentamicin-resistant enterococci infections.
  • To inform targeted infection control strategies for at-risk patient populations.

Main Methods:

  • A case-controlled study was conducted involving patients infected with resistant and sensitive enterococcal strains.
  • Data collected from 17 patients with HLG શ્રે infections and 26 patients with sensitive strains at a London hospital.

Main Results:

  • Prior prolonged antibiotic treatment emerged as a significant risk factor for HLG શ્રે.
  • The use of five or more antibiotics was strongly associated with HLG શ્રે acquisition.
  • Presence of a urinary catheter was identified as a key risk factor for HLG શ્રે infection.

Conclusions:

  • Infection control measures should prioritize patients exhibiting identified risk factors for HLG શ્રે.
  • Stricter antibiotic stewardship within hospitals may reduce the incidence and spread of HLG શ્રે.

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