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Related Experiment Videos

Aging effects on drug disposition and effect.

D R Abernethy1

  • 1abernetd@medlib.georgetown.edu

Geriatric Nephrology and Urology
|August 6, 1999
PubMed
Summary

Older adults often face medication challenges. Understanding "therapeutic burden" is crucial, as drug therapy can cause harm alongside benefits in the aged population.

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Area of Science:

  • Gerontology
  • Pharmacology
  • Clinical Medicine

Background:

  • Traditional advice for drug therapy in older adults is "start low and go slow."
  • The concept of "therapeutic burden" is increasingly important, considering medication number and dosage.
  • Drug therapy in the aged can improve quality of life but also cause significant morbidity.

Purpose of the Study:

  • To discuss the evolving understanding of drug therapy in older individuals.
  • To highlight the significance of "therapeutic burden" in geriatric pharmacotherapy.
  • To review how aging pathophysiology impacts drug response in the elderly.

Main Methods:

  • Review of epidemiologic and surveillance data on drug therapy in older patients.
  • Discussion of advances in understanding the pathophysiology of aging.
  • Analysis of age-related changes in drug response.

Main Results:

  • Drug therapy in older adults presents a dual effect: improving quality of life and causing morbidity.
  • The "therapeutic burden" is a key factor in managing medications for the aged.
  • Understanding individual aging processes is vital for predicting drug responses.

Conclusions:

  • Drug therapy for older adults requires careful consideration of "therapeutic burden."
  • Further research into age-related pharmacokinetics and pharmacodynamics is essential.
  • Personalized approaches to medication management can mitigate risks in the elderly.

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