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Y-chromosome and mitochondrial DNA polymorphisms in Indian populations
K Thangaraj1, G V Ramana, L Singh
1Center for Cellular and Molecular Biology, Hyderabad, India.
Abstract:
Y-chromosome polymorphism using short tandem repeat (STR) markers on 94 normal males belonging to the Brahmin and Kamma caste populations of Andhra Pradesh, India, and Siddis, a migrant population from Africa, inhabiting Hyderabad, India, revealed heterogeneity as indicated by network analysis. We have observed population-specific haplotypes and alleles. Analysis of Y-Alu polymorphism (YAP) in Siddis showed the presence of Alu insertion in 40% of the individuals. However, YAP insertion was not found in Brahmins and Kammas. The dendrogram based on hypervariable region I (HVR I) of the displacement loop (D-loop) sequence of mitochondrial DNA (mtDNA) of Siddis showed genetic relationships to African populations. YAP and mtDNA analysis of Siddis also confirmed their immigration from Africa.