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Related Experiment Videos

Abdominal obesity increases overnight cortisol excretion.

M Duclos1, J B Corcuff, N Etcheverry

  • 1Service d'Endocrinologie, Hôpital Haut-Lévêque, Pessac, France. Martine.Duclos@biosport.u-Bordeaux2.fr

Journal of Endocrinological Investigation
|August 6, 1999
PubMed
Summary

Obese females with abdominal body fat distribution show subtle differences in cortisol regulation, impacting their hypothalamo-pituitary-adrenal axis. These findings highlight potential links between body fat patterns and hormonal balance.

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Area of Science:

  • Endocrinology
  • Obesity Research
  • Human Physiology

Background:

  • Obesity is linked to hypothalamo-pituitary-adrenal (HPA) axis alterations.
  • Previous studies suggest minor HPA axis differences in abdominal vs. peripheral body fat distribution (A-BFD vs. P-BFD).
  • Novel methods for assessing cortisol secretion are needed to explore these subtle differences.

Purpose of the Study:

  • To investigate HPA axis activity in obese females based on body fat distribution.
  • To compare cortisol secretion patterns using advanced methods like saliva cortisol and overnight urinary free cortisol to creatinine ratio (UFC/UC).

Main Methods:

  • Recruited 82 obese female inpatients.
  • Assessed body fat distribution using waist-to-hip ratio (WHR) and waist girth (WG) corrected for age.

Related Experiment Videos

  • Measured plasma and saliva cortisol, 24-hour and overnight UFC/UC, and performed dexamethasone suppression tests.
  • Analyzed routine biochemical parameters and blood pressure.

    • Main Results:

    • Central obesity was prevalent (64% WHR, 87% WG).
    • Abdominal obesity was associated with higher hypertension, triglycerides, cholesterol, and glycemia.
    • Saliva cortisol was lower in A-BFD (WG classification), and overnight UFC/UC was higher in A-BFD (WHR classification).
    • Plasma cortisol levels were similar between groups.

    Conclusions:

    • Mild differences in nocturnal cortisol secretion and free cortisol indexes exist between obese females with different body fat distributions.
    • These findings suggest a subtly different spontaneous regulation of the HPA axis in A-BFD subjects.
    • Body fat distribution may influence HPA axis activity independently of overall obesity.