Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Semantic dysfunction in frontotemporal lobar degeneration.

J S Snowden1

  • 1Department of Neurology, Manchester Royal Infirmary, Manchester, UK. jsnowden@fs1.cmht.nwest.nhs.uk

Dementia and Geriatric Cognitive Disorders
|August 7, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.

Neuropathology and applied neurobiology·2018
Same author

Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.

Neuropathology and applied neurobiology·2015
Same author

Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes.

Neuropathology and applied neurobiology·2012
Same author

Working memory in Alzheimer's disease and frontotemporal dementia.

Behavioural neurology·2011
Same author

Arithmetic knowledge in semantic dementia: is it invariably preserved?

Neuropsychologia·2008
Same author

Emotion recognition in Huntington's disease and frontotemporal dementia.

Neuropsychologia·2008
Same journal

A Longitudinal Analysis of Frontotemporal Dementia Patients in Spain Throughout the COVID-19 Pandemic: A Descriptive Study.

Dementia and geriatric cognitive disorders·2026
Same journal

Understanding Discrepancies and Predictors of Self- versus Proxy-Rated Quality of Life in Chinese Community-Dwelling Older Adults with Mild Dementia: A Cross-Sectional Study.

Dementia and geriatric cognitive disorders·2026
Same journal

An Investigation of the Psychometric Properties of the Farsi Version of the Saint Louis University Mental Status (SLUMS) Examination.

Dementia and geriatric cognitive disorders·2026
Same journal

Examining the decision to take a dementia risk test: Considerations for privacy in screening at-home.

Dementia and geriatric cognitive disorders·2026
Same journal

Caregiving Models and Cognitive Decline in Middle-aged and Older Adults with Limitations in Activities of Daily Living: A CHARLS Cohort Study (2011-2020).

Dementia and geriatric cognitive disorders·2026
Same journal

Utility of Fox and Reverse Fox Finger Imitation Tasks for Screening Cognitive Impairment in Older Adults: A Neuroimaging Study.

Dementia and geriatric cognitive disorders·2026
See all related articles

Semantic dementia, a condition causing word meaning loss and recognition issues, stems from temporal lobe degeneration. Its symptoms can be misdiagnosed, highlighting the need for better recognition of semantic dysfunction.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Semantic dementia is a clinical manifestation of frontotemporal lobar degeneration.
  • It involves atrophy of the inferior and middle temporal gyri.
  • Symptoms include loss of word meaning and impaired recognition of faces and objects.

Purpose of the Study:

  • To describe the clinical characteristics of semantic dementia.
  • To differentiate it from other neurodegenerative conditions like Alzheimer's disease and frontotemporal dementia (FTD).
  • To highlight the link between semantic dementia and FTD.

Main Methods:

  • Clinical observation and description of patients with semantic dementia.
  • Correlation of clinical symptoms with patterns of temporal lobe atrophy.

Related Experiment Videos

  • Comparison of semantic dementia symptoms with those of FTD and Alzheimer's disease.

    • Main Results:

    • Semantic dementia presents with predominant verbal or nonverbal deficits, reflecting left or right temporal lobe atrophy.
    • Behavioral changes can occur, often with an obsessional quality.
    • Overlap in symptoms with FTD is noted, especially as the disease progresses.

    Conclusions:

    • Semantic dysfunction is often underrecognized and can be mistaken for Alzheimer's disease amnesia.
    • Understanding semantic dementia is crucial for explaining behavioral characteristics in focal cerebral degeneration.
    • Semantic dementia reinforces the link between frontotemporal lobar degeneration syndromes.