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Role of oxidative stress in frontotemporal dementia
J L Gerst1, S L Siedlak, A Nunomura
1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Dementia and Geriatric Cognitive Disorders
|August 7, 1999
Abstract:
Recent reports have established oxidative stress and damage as playing a role in the pathogenesis of a number of neurodegenerative diseases including Alzheimer disease, Parkinson disease, corticobasal degeneration, Pick's disease and Alexander's disease. Here we present evidence that oxidative damage is also one of the earliest cytopathological markers of neuronal dysfunction in frontotemporal dementia.