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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Gastric emptying in trauma patients.
C B Carlin1, P H Scanlon, D A Wagner
1Department of Medical Education, Carraway Methodist Medical Center, Birmingham, AL, USA.
Digestive Surgery
|August 7, 1999
Summary
Trauma patients exhibit delayed gastric emptying, with minimal recovery within a week. Early nutritional support should utilize transpyloric feeding rather than gastric feeding due to impaired gastric emptying.
Area of Science:
- Gastroenterology
- Trauma Medicine
- Nutritional Support
Background:
- Gastric emptying is crucial for effective enteral nutrition.
- Trauma can significantly impact gastrointestinal function.
- Quantitative data on post-trauma gastric emptying is limited.
Purpose of the Study:
- To quantify gastric emptying in trauma patients.
- To assess the recovery of gastric emptying over one week post-trauma.
- To inform optimal timing and route for early nutritional intervention in trauma.
Main Methods:
- Utilized L-[1-(13)C]phenylalanine absorption to measure gastric emptying.
- Administered L-[1-(13)C]phenylalanine nasogastrically to 14 trauma patients.
- Measured plasma enrichment and expired (13)CO(2) at 24 hours and 7 days post-admission.
Main Results:
- Significantly delayed gastric emptying observed in trauma patients compared to controls.
- A fivefold increase in plasma L-[1-(13)C]phenylalanine enrichment noted from initial to second study.
- Over a sixfold increase in (13)CO(2) exhalation, indicating improved but still limited gastric emptying after 7 days.
Conclusions:
- Gastric emptying is significantly delayed in trauma patients with slow recovery.
- Gastric feeding is not recommended for early nutritional support in trauma.
- Transpyloric feeding is the preferred route for early nutritional intervention in trauma patients.
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