Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multipoint linkage analysis. A cautionary note.

J Halpern1, A S Whittemore

  • 1Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305-5405, USA.

Human Heredity
|August 7, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased retention of tau PET ligand [<sup>18</sup>F]-AV1451 in Alzheimer's Disease Psychosis.

Translational psychiatry·2022
Same author

A price tag on clinical empathy? Factors influencing its cost-effectiveness.

Journal of the Royal Society of Medicine·2020
Same author

Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic <i>Escherichia coli</i> as a prophylactic against diarrhea.

Gut microbes·2020
Same author

Ethical, moral, and theological insights into advances in male pediatric and adolescent fertility preservation.

Andrology·2017
Same author

Trainee perspectives on postdoctoral recruitment in clinical neuropsychology: reflections on commentaries by Bodin and Grote (2016) and Nelson et al. (2016).

The Clinical neuropsychologist·2017
Same author

Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey.

The British journal of dermatology·2015
Same journal

Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

Human heredity·2026
Same journal

Erratum.

Human heredity·2026
Same journal

Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

Human heredity·2025
Same journal

Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

Human heredity·2025
Same journal

Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

Human heredity·2025
Same journal

Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

Human heredity·2025
See all related articles

Multipoint linkage analysis can be powerful but is sensitive to errors in marker distance. For confirming previous findings with modest significance, single-point analysis may offer more reliable linkage support measures.

Area of Science:

  • Genetics
  • Statistical genetics
  • Bioinformatics

Background:

  • Multipoint linkage analysis leverages haplotype information from multiple markers to infer identity by descent (IBD) relations, enhancing power when IBD status is ambiguous.
  • This method is commonly applied to assess disease linkage within small genomic regions.

Purpose of the Study:

  • To compare the statistical power of single-point and multipoint linkage analyses.
  • To evaluate the impact of misspecified intermarker distances on the reliability of these analyses, particularly for closely spaced markers.

Main Methods:

  • Computer simulations were conducted to compare the performance of single-point and multipoint analyses.
  • Simulations assessed power under conditions of ambiguous IBD relations and misspecified intermarker distances.

Related Experiment Videos

Main Results:

  • Multipoint analysis is sensitive to power loss when intermarker distances are inaccurately specified, especially with closely spaced markers.
  • Single-point analysis may provide more dependable measures of linkage support in situations requiring confirmation of previous findings with modest statistical significance.

Conclusions:

  • While multipoint analysis offers advantages in inferring IBD, its reliability can be compromised by inaccurate genetic map information.
  • For specific research scenarios, such as validating prior linkage results, single-point analysis might be a more robust choice due to its lower sensitivity to distance misspecification.