Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk factors for biliary tract carcinogenesis.

R W Chapman1

  • 1Dept of Gastroenterology, Oxford Radcliffe Hospital, Headington, UK.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|August 7, 1999
PubMed
Summary

Cholangiocarcinoma, a primary liver cancer, is linked to chronic inflammation and biliary tract injury. Risk factors include primary sclerosing cholangitis and congenital fibropolycystic diseases, increasing cancer development risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Uterine Polypus Removed by the Ligature, in Which Dilatation of the Os Uteri Was Produced by the Administration of the Lobelia Inflata.

Edinburgh medical and surgical journal·2018
Same author

Editorial: vancomycin - a promising option for the treatment of primary sclerosing cholangitis?

Alimentary pharmacology & therapeutics·2018
Same author

Early primary biliary cholangitis is characterised by brain abnormalities on cerebral magnetic resonance imaging.

Alimentary pharmacology & therapeutics·2016
Same author

A rare cause of colonic thickening and lymphadenopathy.

Gut·2016
Same author

Editorial: further evidence for the role of serum alkaline phosphatase as a useful surrogate marker of prognosis in PSC.

Alimentary pharmacology & therapeutics·2014
Same author

Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort.

The American journal of gastroenterology·2014

Area of Science:

  • Hepatobiliary Malignancy
  • Gastroenterology
  • Oncology

Background:

  • Cholangiocarcinoma accounts for 10-15% of primary hepatobiliary cancers globally.
  • Risk factors often involve chronic inflammation and injury to the biliary epithelium.
  • Primary sclerosing cholangitis, associated with inflammatory bowel disease, increases cholangiocarcinoma risk (10-20% of patients).

Purpose of the Study:

  • To review the known risk factors associated with cholangiocarcinoma development.
  • To highlight the link between chronic biliary inflammation and cancer.
  • To discuss specific conditions that elevate cholangiocarcinoma risk.

Main Methods:

  • Literature review of epidemiological and etiological factors for cholangiocarcinoma.
  • Analysis of associations between biliary diseases and cancer incidence.
  • Examination of risk stratification based on age and specific conditions.

Main Results:

  • Chronic inflammation is a common pathway for cholangiocarcinoma development.
  • Primary sclerosing cholangitis and congenital fibropolycystic diseases (e.g., choledochal cysts) significantly increase risk.
  • Liver fluke infestation (Far East) and cirrhosis are also linked to cholangiocarcinoma.

Conclusions:

  • Identifying and managing risk factors like chronic biliary inflammation is crucial for cholangiocarcinoma prevention.
  • Congenital biliary diseases require careful monitoring due to elevated cancer risk.
  • Further research into etiological factors may improve early detection and treatment strategies.

Related Experiment Videos