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[The antibacterial activity of cefmetazole and other antibiotics to 463 isolates]

Y Xu1, H Wang, M Chen

  • 1Peking Union Medical College Hospital, Beijing.

Zhonghua Nei Ke Za Zhi
|August 1, 1997
PubMed

Insights

Cefmetazole demonstrates strong in-vitro antibacterial activity against common clinical isolates, including Enterobacteriaceae and oxacillin-sensitive staphylococci. This study compared its efficacy against four other antibiotics.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antibiotic resistance is a growing global health concern.
  • Evaluating the efficacy of existing and novel antibiotics is crucial for effective treatment strategies.
  • Cefmetazole is a cephalosporin antibiotic with a broad spectrum of activity.

Purpose of the Study:

  • To compare the in-vitro antibacterial activity of cefmetazole against clinical isolates.
  • To determine the minimal inhibitory concentration (MIC) of cefmetazole and other antibiotics.
  • To assess cefmetazole's effectiveness against specific bacterial species, including Enterobacteriaceae and staphylococci.

Main Methods:

  • Standard (NCCLS) agar dilution testing was employed.
  • Minimal inhibitory concentrations (MICs) were determined for cefmetazole, cefazolin, cefuroxime, cefotaxime, and ceftazidime.
  • Testing was performed on 463 clinical isolates.

Main Results:

  • Cefmetazole exhibited the highest efficacy against indole-positive Proteus vulgaris and Morganella morganii (MIC(90) 8 mg/L).
  • Against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, cefmetazole showed comparable activity to cefotaxime but less than ceftazidime.
  • Cefmetazole was highly active against oxacillin-sensitive staphylococci (MIC(90) 4 mg/L).

Conclusions:

  • Cefmetazole demonstrates significant in-vitro antibacterial activity against Enterobacteriaceae.
  • Cefmetazole is highly effective against oxacillin-sensitive staphylococci.
  • Cefmetazole represents a valuable therapeutic option for infections caused by these susceptible pathogens.

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