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[Significance of proteinuria in patients with acute ischemic brain disease]
Insights
Proteinuria is common in patients with ischemic brain disease (IBD). Higher proteinuria levels correlate with IBD severity, suggesting a link to atherosclerosis and potential predictive value for disease outcomes.
Area of Science:
- Neurology
- Nephrology
- Vascular Medicine
Context:
- Brain vascular diseases are a leading cause of death globally.
- Ischemic brain disease (IBD), often caused by atherosclerosis, accounts for 80% of vascular brain diseases.
- Recent findings suggest a link between atherosclerosis and proteinuria.
Purpose:
- To investigate the association between proteinuria and clinical parameters in patients with ischemic brain disease (IBD).
- To determine the frequency and patterns of proteinuria in IBD patients.
- To explore the relationship between proteinuria degree and IBD severity.
Summary:
- A study of 180 IBD patients and 60 controls found significant proteinuria in IBD cases.
- Proteinuria degree strongly correlated with IBD severity and functional/neurologic impairment.
- Quantitative proteinuria assessment and standardized scales were used to evaluate IBD and patient outcomes.
Impact:
- Proteinuria may be linked to the atherogenic and pathophysiologic processes of IBD.
- Proteinuria could serve as an early predictive marker for IBD outcomes.
- Findings highlight the importance of monitoring proteinuria in IBD management.
Abstract:
Brain vascular diseases are ranked the third as the cause of morbidity and mortality in majority of the countries of the world. In about 80% of the cases of vascular brain diseases, it is ischemic brain disease (IBD). Atherosclerosis of main cerebral arteries is most frequently responsible for the occurrence and development of IBD. In recent years it was reported for the first time of the association of atherosclerosis and/or its complications and proteinuria. Assuming that there exists the significant association between the degree of proteinuria and clinical parameters of IBD, the aim of this study was to investigate the frequency and patterns of the association of proteinuria and clinical IBD parameters. The study was performed in 180 patients with IBD of atherothrombotic origin and 60 patients with the diseases of non-vascular origin, as the control group. In all patients quantitative determination of proteinuria was performed, and in the patients with IBD was determined the degree of IBD and afterwards the degree of functional and neurologic impairment prior to and at the end of treatment in acute phase using the standardized scales. The results of the study revealed the existence of significant frequency of proteinuria in the patients with IBD, as well as the significant association between the degree of proteinuria and severity of IBD. It was concluded that proteinuria in patients with IBD was probably associated with the atherogenic processes and physiopathologic processes of IBD, respectively, which could have predictive value for the outcome of the disease in the early stage.