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Safety and efficacy of angiotensin II receptor antagonists

J M Neutel1

  • 1Orange County Heart Institute and Research Center, Orange, California 92668, USA.

The American Journal of Cardiology
|August 7, 1999
PubMed

Insights

Hypertension management is failing globally, with inadequate blood pressure control increasing heart disease risk. Angiotensin II receptor antagonists offer effective 24-hour blood pressure control and better patient compliance compared to other agents.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Global hypertension management shows a concerning trend of increased treatment but failing to reach target blood pressure levels.
  • Inadequate blood pressure control is a significant risk factor for developing coronary artery disease.

Purpose of the Study:

  • To compare the safety and efficacy of angiotensin II receptor antagonists with other antihypertensive medications.
  • To address the challenges of poor drug efficacy, side effects, and patient compliance in hypertension management.

Main Methods:

  • Utilized ambulatory blood pressure monitoring to assess 24-hour blood pressure control.
  • Compared angiotensin II receptor antagonists against other antihypertensive agents.

Main Results:

  • Angiotensin II receptor antagonists demonstrated adequate 24-hour blood pressure control.
  • These agents exhibited a side-effect profile comparable to placebo.
  • Once-daily dosing of angiotensin II receptor antagonists improved patient compliance.

Conclusions:

  • Angiotensin II receptor antagonists represent a promising therapeutic option for improving hypertension management.
  • These agents offer a favorable balance of efficacy, safety, and patient compliance.

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