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R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type
R D Berkowitz1, A B van't Wout, N A Kootstra
1Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA.
Journal of Virology
|August 10, 1999
Abstract:
Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.
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