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Preferential binding of mouse mammary tumor virus to B lymphocytes
F Baribaud1, A V Shaw, L Scarpellino
1Institute of Microbiology, University of Lausanne, CH-1011 Lausanne, CH-1066 Epalinges, Switzerland. fbaribau@mail.med.upenn.edu
Abstract:
Mouse mammary tumor virus (MMTV) has been shown to preferentially infect B lymphocytes in vivo. We have used recombinant envelope-coated fluospheres and highly purified MMTV particles to study the distribution of the viral receptors on fresh mouse lymphocytes. A preferential dose-dependent binding to B lymphocytes was observed which could be competed with neutralizing antibodies. In contrast, T-lymphocyte binding remained at background levels. These results strongly suggest a higher density of viral receptor molecules on B lymphocytes than on T lymphocytes and correlate with the preferential initial infection of B lymphocytes observed in vivo.