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Haptoglobin genotype and natural fertility in humans
N Bottini1, A Gimelfarb, F Gloria-Bottini
1University of Camerino, Italy. nunzio.bottini@uniroma2.it
Objective:
To study the possible relation between human natural fertility and haptoglobin (Hp) genotype.
Design:
Prospective study.
Setting:
Maternity departments of local hospitals in two Italian localities.
Patient(S):
Healthy women who had just given birth in the maternity departments of two local hospitals (n = 679).
Intervention(S):
Venous blood collection for determination of Hp genotype with the use of starch gel electrophoresis of hemoglobin-supplemented serum.
Main Outcome Measure(S):
Distribution of Hp genotypes in relation to age of puerperae.
Result(S):
In both populations, the proportion of young mothers was much higher among women who were homozygous for the Hp*1 allele (the Hp*1/*1 genotype) than among women who had other Hp genotypes. In addition, the proportion of multiparous women among the older mothers was higher among those with the Hp*1/*1 genotype than among those with other Hp genotypes.
Conclusion(S):
The data suggest that women with the Hp*1/*1 genotype reproduce at an earlier age and have higher natural fertility potential than women with other Hp genotypes.
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