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Related Experiment Videos

Diabetic embryopathy.

B G Kousseff1

  • 1University of South Florida, Department of Pediatrics, Tampa 33617-3451, USA. bkoussef@com1.med.usf.edu

Current Opinion in Pediatrics
|August 10, 1999
PubMed
Summary
This summary is machine-generated.

Maternal diabetes mellitus (DM) causes birth defects known as diabetic embryopathy (DE). Research is ongoing to understand DE, especially in gestational DM, to improve infant outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Endocrinology

Background:

  • Maternal pregestational diabetes mellitus (DM) classes B-T is a known teratogen, causing diabetic embryopathy (DE).
  • Gestational DM (classes A1 and A2) is not yet recognized as a teratogen due to late diagnosis and unclear pathogenesis.
  • DM affects approximately 5% of pregnancies, necessitating continued research into DE.

Purpose of the Study:

  • To review recent research (1997-1998) on diabetic embryopathy (DE).
  • To increase pediatrician awareness of DE and its potential role in unexplained congenital malformations.
  • To highlight the need for further understanding of DE pathogenesis.

Main Methods:

  • Literature review of laboratory and clinical research from 1997-1998.

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  • Synthesis of findings related to maternal diabetes and congenital malformations.
  • Focus on aspects relevant to pediatricians.

    • Main Results:

    • Established teratogenicity of pregestational DM (classes B-T) leading to DE.
    • Ongoing debate and research into the teratogenic potential of gestational DM.
    • Identification of DE as a significant factor in congenital malformations.

    Conclusions:

    • Increased awareness of DE is crucial for pediatricians.
    • Further research is needed to elucidate the pathogenesis of DE, particularly in gestational DM.
    • Understanding DE may help identify causes of "idiopathic" malformations.