[A morphofunctional analysis of the early changes in cardiomyocyte structure and metabolism in acute coronary...

Initial morphological and cytochemical cardiomyocyte alterations were studied at experimental acute coronary failure by histological, electron microscopy and electron histochemical methods. The results obtained demonstrated that transition of contractile myocardium to emergency function occurring at experimental conditions is accompanied by a strict rise of structural and functional heterogeneity. Prior to this process a functional and conformational unification of mitochondria takes place, passing to progress of pathological process, destructive changes of organellae causing cell death. Appearance of cellular insufficiency is acting upon all energy dependent processes: contractile cycle efficiency, function of calcium transferring systems Ca-binding sarcoplasmic reticulum function and that of mitochondria, as well efficiency of regenerative mechanisms. In appearing condition ruining of every cardiomyocyte system is possible.