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Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?
K F Wong1, Y M Zhang, J K Chan
1Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China. kfwong@ha.org.hk
Leukemia & Lymphoma
|August 10, 1999
Summary
Natural killer (NK) cell lymphomas, also known as NK/T cell lymphomas, frequently exhibit chromosomal abnormalities. Deletions in the 6q21-23 region are the most common genetic alteration found in these rare lymphoid neoplasms.
Area of Science:
- Hematology
- Oncology
- Cytogenetics
Background:
- Natural killer (NK)/T cell lymphomas are uncommon lymphoid neoplasms characterized clinically in recent years.
- Limited information exists regarding the cytogenetic and molecular alterations in these tumors.
Purpose of the Study:
- To review the literature on chromosomal abnormalities in NK/T cell lymphomas.
- To identify recurrent genetic alterations and their potential role in pathogenesis.
Main Methods:
- Literature review of published studies on NK/T cell lymphomas.
- Analysis of reported chromosomal abnormalities, including fluorescence in situ hybridization (FISH) findings.
Main Results:
- Chromosomal abnormalities are common in NK/T cell lymphomas.
- Aberrations involving chromosome 6q are the most frequent, specifically deletions at 6q21-23.
- Other non-random abnormalities include +X, i(1q), i(7q), +8, del(13q), del(17p), i(17q), and 11q23 rearrangement.
Conclusions:
- Deletions at chromosome 6q22-23 are the most common recurrent chromosomal abnormality in CD3- CD56+ NK/T cell lymphomas.
- Further investigation of genes within the 6q region may elucidate the molecular pathogenesis of these neoplasms.