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Related Experiment Videos

Autoimmunity in Waldenström's macroglobulinaemia.

V Jønsson1, A Kierkegaard, S Salling

  • 1Department of Hematology, Rigshospital, University of Copenhagen, Denmark.

Leukemia & Lymphoma
|August 10, 1999
PubMed
Summary

Autoimmune diseases are common in Waldenström's Macroglobuliemia, affecting over half of patients. These manifestations often appear after diagnosis and include hemolytic anemia and rheumatoid arthritis.

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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Waldenström's Macroglobuliemia (WM) is a rare B-cell lymphoproliferative disorder.
  • Autoimmune phenomena are increasingly recognized in lymphoproliferative disorders.
  • The spectrum and prevalence of autoimmune manifestations in WM require further elucidation.

Purpose of the Study:

  • To retrospectively investigate the frequency and types of autoimmune manifestations in a cohort of WM patients.
  • To determine the temporal relationship between WM diagnosis and the onset of autoimmune conditions.
  • To explore potential correlations between autoimmune manifestations and clinical/laboratory features of WM.

Main Methods:

  • Retrospective analysis of 57 consecutive patients diagnosed with Waldenström's Macroglobuliemia.

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  • Review of clinical records and serological data to identify autoimmune manifestations.
  • Categorization of autoimmune conditions, including Coombs' positive hemolytic anemia, rheumatoid arthritis, and IgM-cardiolipin syndrome.

    • Main Results:

    • 51% of patients exhibited clinical and/or serological autoimmune manifestations.
    • Autoimmune hemolytic anemia and seropositive rheumatoid arthritis were the most common (16% each).
    • Inflammatory gastric ulcer (12%) and IgM-cardiolipin syndrome (11%) were also prevalent; 40% of autoimmune issues were present at WM diagnosis.

    Conclusions:

    • Autoimmune manifestations are frequent in Waldenström's Macroglobuliemia.
    • These conditions can precede or follow WM diagnosis, impacting patient management.
    • A correlation between gastric ulcers, parietal cell autoantibodies, and Helicobacter pylori infection was observed.