Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II
S Eguchi1, H Iwasaki, Y Hirata
1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. satoru.eguchi@vanderbilt.edu
Abstract:
We have reported that angiotensin II induces the epidermal growth factor (EGF) receptor transactivation leading to extracellular signal-regulated kinase (ERK) activation in rat vascular smooth muscle cells. Here, we report that the EGF receptor kinase inhibitor AG1478 and the ERK kinase inhibitor PD98059 markedly inhibited angiotensin II-induced c-Fos expression and protein synthesis but not c-Jun expression in these cells. These data suggest that the EGF receptor transactivation and subsequent ERK activation are indispensable for angiotensin II-mediated growth promotion of vascular smooth muscle cells providing a new mechanistic insight whereby angiotensin II contributes abnormal vascular remodeling.
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