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Viral RNA and evolved mutational robustness.

A Wagner1, P F Stadler

  • 1Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131-1091, USA. wagnera@unm.edu

The Journal of Experimental Zoology
|August 10, 1999
PubMed
Summary
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This study provides evidence that the robustness of RNA virus genomes to mutations has evolved. This finding suggests that genetic robustness may be an adaptive trait rather than an intrinsic property of genetic systems.

Area of Science:

  • Evolutionary biology
  • Molecular evolution
  • Virology

Background:

  • Organismal properties often exhibit robustness against mutations.
  • It remains unclear whether this robustness is an evolved trait or an intrinsic characteristic of genetic systems.

Purpose of the Study:

  • To investigate whether the mutational robustness of RNA virus genomes has evolved.
  • To challenge existing concepts in molecular evolution if robustness is found to be an evolved property.

Main Methods:

  • Analysis of RNA virus genomes.
  • Assessment of mutational changes in secondary structure.

Main Results:

  • Evidence suggests that the mutational robustness of RNA virus genomes has evolved.

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  • This implies that robustness is not solely an intrinsic property of genetic systems.

    • Conclusions:

    • The evolution of mutational robustness in RNA viruses is supported.
    • This finding necessitates a re-evaluation of fundamental concepts in molecular evolution, including mutation rates and the impact of deleterious mutations.