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Glycemic control and cardiovascular disease in type 2 diabetes: a review

S H Wild1, C J Dunn, P M McKeigue

  • 1Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Sarah.Wild@nwanglia.anglox.nhs.uk

Diabetes/Metabolism Research and Reviews
|August 10, 1999
PubMed

Insights

People with Type 2 diabetes face high cardiovascular disease risks. Managing hypertension and hyperlipidemia is crucial for reducing this risk, potentially more effectively than solely focusing on glycemic control.

Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Diseases

Background:

  • Type 2 diabetes significantly elevates cardiovascular disease (CVD) risk, including atherosclerotic disease.
  • This increased risk in diabetic patients surpasses that explained by common comorbidities like hypertension and hyperlipidemia.

Purpose of the Study:

  • To review the impact of hyperglycemia and glycemic control on CVD in Type 2 diabetes.
  • To synthesize findings from prospective observational studies and randomized controlled trials.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of prospective observational studies.
  • Evaluation of randomized controlled trials (RCTs).

Main Results:

  • Elevated blood glucose levels (hyperglycemia) play a role in CVD development in Type 2 diabetes.
  • Effective management of hypertension and hyperlipidemia is vital for CVD risk reduction.
  • Achieving tight glycemic control may be more challenging than managing other cardiovascular risk factors.

Conclusions:

  • Controlling hypertension and hyperlipidemia are key strategies to mitigate CVD risk in individuals with Type 2 diabetes.
  • These interventions may offer a more attainable approach to risk reduction compared to stringent glycemic control alone.

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