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Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment

A C Hayday1, D F Barber, N Douglas

  • 1Department of Immunobiology, Guy's King's St Thomas Medical School, University of London, Guy's Hospital Campus, London, SE1 9RT, UK,

Seminars in Immunology
|August 11, 1999
PubMed
Summary

Understanding T cell lineage commitment requires examining signals from the pre T cell receptor (preTCR) and TCRgammadelta. These signals, alongside others, are crucial for determining whether a progenitor cell becomes an alphabeta or gammadelta T cell.

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