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Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s)
1Department of Medicine, The Arthritis and Immune Disorder Research Centre, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Abstract:
The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCRgammadelta or TCRalphabeta. Here we discuss the role of MHC in the development and selection of gut-derived T cells. Through the analysis of iIEL selection in animals expressing a transgenic TCRalphabeta, in the presence or absence of p56(lck), we discuss lineage relationships among CD4(-)8(+) iIEL subsets, and their possible function(s).