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Malignant mesothelioma in Israel, 1961-1992.

J Iscovich1, A Fischbein, J Witt-Kushner

  • 1The International Fertility Institute, 142 Achuza Street, Ra'anana, 43300, Israel. iscovich@mail.netvision.net.il

International Journal of Occupational and Environmental Health
|August 11, 1999
PubMed
Summary

Malignant mesothelioma incidence increased in Israeli men, with rising male-to-female ratios. Early onset suggests younger asbestos exposure ages, indicating future impacts are yet to be seen.

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Area of Science:

  • Epidemiology
  • Occupational Health
  • Oncology

Background:

  • Malignant mesothelioma is a rare cancer strongly linked to asbestos exposure.
  • Understanding temporal trends in incidence and risk factors is crucial for public health.
  • Previous studies have focused on occupational cohorts, but population-based trends require investigation.

Purpose of the Study:

  • To analyze time trends in malignant mesothelioma incidence and distribution in Israel from 1961 to 1992.
  • To investigate changes in the male-to-female incidence ratio and identify risk factors.
  • To assess the age at diagnosis and compare asbestos exposure patterns with European countries.

Main Methods:

  • Monitored time trends in malignant mesothelioma incidence and distribution among 223 Israeli individuals.

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  • Included a cohort of 3,057 asbestos-cement workers (83,122 person-years).
  • Analyzed incidence rates, male-to-female ratios, and age at diagnosis, excluding direct occupational exposure cases.

    • Main Results:

    • Annual incidence rates in Jewish men increased from 2.5/million (1961-82) to 4.6/million (1985-92).
    • The male-to-female incidence ratio rose from 1.2 to 2.9, driven by increased risk in Israeli-born males.
    • Most cases (91%) lacked direct occupational asbestos exposure; female incidence remained stable after 1961.

    Conclusions:

    • Rising malignant mesothelioma rates in Israeli men, particularly Israeli-born, suggest increasing non-occupational asbestos exposure.
    • The early age of onset indicates younger exposure ages in Israel compared to Europe.
    • Asbestos use peaked in the mid-1970s, implying the full impact of these trends is still emerging.