Modelling study quality in meta-analysis
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1Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.
Abstract:
When summarizing studies in a meta-analysis, the methodological quality of the studies can vary widely. This variation is often described by assigning quality scores to studies. This paper presents a probability model for the effect of quality on a summary effect measure. The model motivates criteria used to assess quality, and can be used to incorporate quality into the calculation of a summary effect. We derive a number of summarization methods and compare them for simulated data and an actual set of studies.
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