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Imaging Cell Membrane Injury and Subcellular Processes Involved in Repair
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[Reparative processes and immunity]

A G Babaeva1

  • 1Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.

Izvestiia Akademii Nauk. Seriia Biologicheskaia
|August 12, 1999
PubMed

The published and author's data concerning changes in formation of antibodies to T-dependent antigen during regeneration of various organs in mammals are summarized. Significance of stress, functional transgression of the injured organs, products of tissue degradation and degree of organ tissue deficit for postoperative stimulation of antibody formation has been discussed. Interaction between the organ antigens and lymphoid tissue was shown to be important for changes of immunoreactivity. Dependence of the immune system postoperative stimulation on the organ tissue deficit is connected with the increase of the T-helpers/T-suppressors ratio in the spleen of operated animals. It has been proposed that the mechanism underlying the action of organ tissue deficit is connected with the loss of natural immunological tolerance to organospecific autoantigens.

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