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[Acute transverse cervical myelitis following hepatitis B vaccination. Evolution of anti-HBs antibodies]
J L Renard1, J S Guillamo, J M Ramirez
1Clinique de neurologie, HIA Val-de-Grâce, Paris.
Background:
The cause and effect relationship between anti-HBV immunization using recombinant vaccine and the development of a neurological event, including flare-ups of multiple sclerosis, is a widely debated issue.
Case Report:
A previously asymptomatic 16-year-old girl was a hyper-responder to anti-HBV vaccine. Subsequent to a booster shot of anti-HBV recombinant vaccine, she developed regressive acute cervical transverse myelitis with intrathecal oligochonal IgG secretion and a hypersignal on the MRI T2 sequences of the cord.
Discussion:
The distinction between a first episode of multiple sclerosis or post-vaccinal acute myelitis in this case will depend upon subsequent course, but this observation points out the very high level of persistent post-vaccinal immunization which can be acquired by a hyper-responder.
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