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Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration
R J Mathew1, W H Wilson, N Y Chiu
1Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Objective:
The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation.
Method:
Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC.
Results:
After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate.
Conclusion:
Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.
