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Related Experiment Videos

Fetal hematology.

Y Tannirandorn1, B Uerpairojkit, S Manotaya

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|August 12, 1999
PubMed
Summary

Fetal blood cell counts change during pregnancy, with red blood cells and granulocytes increasing while mean corpuscular volume decreases. These findings establish normal fetal hematological parameters for prenatal diagnosis.

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Area of Science:

  • Perinatology
  • Hematology
  • Fetal Medicine

Background:

  • Fetal blood sampling is increasingly used for prenatal diagnosis.
  • Accurate interpretation requires established normal fetal hematological values throughout gestation.

Purpose of the Study:

  • To establish normal fetal hematological parameters across different gestational ages (21-38 weeks).
  • To provide reference values for prenatal diagnosis of fetal blood disorders.

Main Methods:

  • Fetal blood samples were collected from 35 fetuses (21-38 weeks gestation) using ultrasound-guided sampling.
  • Hematological parameters were analyzed within 30 minutes using an automated cell counter.

Main Results:

  • Fetal red blood cell and granulocyte counts significantly increased with advancing gestation.

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  • Mean corpuscular volume showed a significant decrease as gestation progressed.
  • Hemoglobin, hematocrit, and other measured parameters remained stable throughout gestation.
  • Conclusions:

    • Normal reference ranges for fetal hematological parameters have been established.
    • These values are crucial for the accurate prenatal diagnosis of hematological conditions.
    • The study provides essential data for clinical practice in fetal medicine.