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Updated: Aug 5, 2026
08:41
Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
[Structural and functional changes of bone marrow stroma in chronic lymphocytic leukemia]
T A Shatseva1, V I Rugal', A P Novozhilova
1Russian Research Institute of Hematology and Transfusiology, Ministry of Health of the RF, St. Petersburg.
Voprosy Onkologii
|August 12, 1999
Summary
Bone marrow stroma undergoes significant changes in chronic lymphocytic leukemia (CLL). These alterations, including fibrosis and altered cell populations, are linked to both the leukemia and stromal damage.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Context:
- Investigated marrow stroma in 20 patients with chronic lymphocytic leukemia (CLL).
- Examined morphological and functional characteristics of bone marrow stroma.
- Focused on changes associated with both localized and diffuse bone marrow lesions in CLL patients.
Purpose:
- To identify typical morphological and functional changes in the bone marrow stroma of CLL patients.
- To correlate observed stromal changes with the extent and pattern of bone marrow involvement.
- To investigate the potential origins of these stromal alterations, considering both malignant lymphoid cells and intrinsic stromal damage.
Summary:
- Identified adipose tissue reduction, sinusoid obliteration, and increased reticular cells as characteristic of CLL marrow stroma.
- Observed fibrosis, nuclear bodies, and heightened stromal precursor proliferation in subendothelial and perivascular areas in 60% of patients with diffuse lesions.
- Demonstrated pronounced morphological and functional stromal changes, particularly in diffuse bone marrow lesions, suggesting contributions from both the malignant clone and stromal pathology.
Impact:
- Highlights the significant impact of chronic lymphocytic leukemia on bone marrow microenvironment.
- Provides insights into the pathobiology of bone marrow stromal changes in CLL.
- Suggests that stromal integrity may be a critical factor in CLL progression and warrants further investigation.
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