[Standard and hyperfractionated irradiation for locally advanced tumors (T3NOMO) of the larynx]

Two modalities of radiotherapy of locally advanced tumors (T3N0M0) of the larynx were compared in the treatment of 89 patients. Forty-six patients of group I received 2 Gy daily, 5 times a week (COD 65-70 Gy), while 43 patients of group 11--1.1 Gy of multifractionated radiation twice a day, at 4-hr interval (COD 70-75 Gy). Five-year survival in group 1 was 67.1--11%, recurrence-free rate--54 +/- 7.3%, while in group 11--76 +/- 6.5 and 67 +/- 7.1%, respectively, (p < 0.4).