Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha1-adrenoceptor subtypes.

H Zhong1, K P Minneman

  • 1Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA.

European Journal of Pharmacology
|August 12, 1999
PubMed
Summary

Alpha1-adrenoceptors, crucial for adrenaline responses, have subtypes (alpha1A, alpha1B, alpha1D) involved in smooth muscle contraction. Research focuses on subtype-selective drugs and novel signaling pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutron-Multiplicity Measurement in Muon Capture on Oxygen Nuclei in the Gadolinium-Loaded Super-Kamiokande Detector.

Physical review letters·2026
Same author

X-linked hypophosphatemic rickets: a rare case report.

Acta orthopaedica Belgica·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

Effects of drinking water temperature in summer on growth performance, water consumption, surface temperature, blood parameters, and intestinal development of geese from 14 to 42 days of age.

Poultry science·2026
Same author

Results from the T2K Experiment on Neutrino Mixing Including a New Far Detector μ-like Sample.

Physical review letters·2026
Same author

[Comparison of the efficacy of isoperistaltic and antiperistaltic anastomosis in totally laparoscopic right hemicolectomy: a post-hoc analysis based on a national multicenter snapshot study].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Cell Signaling

Background:

  • Alpha1-adrenoceptors are key G protein-coupled receptors mediating adrenaline and noradrenaline effects.
  • Three subtypes (alpha1A, alpha1B, alpha1D) exist, with splice variants reported for alpha1A.
  • These receptors are vital in smooth muscle contraction and are targets for benign prostatic hypertrophy treatments.

Purpose of the Study:

  • To explore the diverse signaling pathways activated by alpha1-adrenoceptors.
  • To investigate subtype-specific differences in receptor coupling and downstream effects.
  • To identify novel drug targets and understand receptor interactions beyond G proteins.

Main Methods:

  • Analysis of G protein coupling efficiencies (G(q/11)) across subtypes.
  • Investigation of second messenger activation, including Ca2+ release and phospholipase activity.
  • Exploration of mitogen-activated protein kinase pathway activation and its regulation.

Main Results:

  • All subtypes activate phospholipase C, Ca2+, and protein kinase C, with varying efficiencies (alpha1A > alpha1B > alpha1D).
  • Additional pathways like Ca2+ influx, arachidonic acid, and phospholipase D activation are involved.
  • Mitogen-activated protein kinase pathways are activated, some independently of Ca2+/protein kinase C, involving small G proteins and tyrosine kinases.

Conclusions:

  • Alpha1-adrenoceptors utilize multiple signaling cascades, including non-traditional pathways.
  • Understanding subtype-specific signaling is crucial for developing selective therapeutics.
  • Future research aims to uncover direct protein interactions and integrate complex signaling networks.

Related Experiment Videos