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Experimental models in asthma.

S T Holgate1

  • 1University Medicine, Southampton General Hospital, Southampton, UK.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|August 12, 1999
PubMed
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Histamine release from mast cells triggers bronchoconstriction and late asthmatic responses. Combining H1-receptor and cysteinyl LT1-receptor antagonists offers a promising new approach for treating allergic asthma.

Area of Science:

  • Allergy and Immunology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Histamine, released by mast cells, is a key mediator in acute bronchoconstriction.
  • Histamine may also play a role in late asthmatic responses by activating basophils.

Purpose of the Study:

  • To investigate the role of histamine and its interaction with other mediators in allergic responses.
  • To evaluate the therapeutic potential of combining H1-receptor and cysteinyl LT1-receptor antagonists in asthma treatment.

Main Methods:

  • Review of existing literature on histamine, mast cells, and allergic asthma.
  • Analysis of the effects of H1-receptor antagonists and cysteinyl LT1-receptor antagonists, individually and in combination.

Main Results:

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  • H1-receptor antagonists partially inhibit histamine-mediated responses.
  • Combined H1-receptor and cysteinyl LT1-receptor antagonists demonstrate greater inhibition, suggesting mediator interaction.

Conclusions:

  • Histamine is a significant mediator in allergic asthma.
  • Combination therapy with selective mediator antagonists presents a novel therapeutic strategy for allergic disorders like asthma.