Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term sound conditioning enhances cochlear sensitivity.

S G Kujawa1, M C Liberman

  • 1Department of Otology and Laryngology, Harvard Medical School; and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.

Journal of Neurophysiology
|August 13, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Cochlear histopathology in macaques after noise-induced temporary threshold shifts.

Hearing research·2026
Same author

Cochlear histopathology in macaques after noise-induced temporary threshold shifts.

bioRxiv : the preprint server for biology·2025
Same author

Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing.

Hearing research·2022
Same author

Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear.

Neuroscience·2018
Same author

Blast-induced cochlear synaptopathy in chinchillas.

Scientific reports·2018
Same journal

Comprehensive Analysis of Auditory Nerve Fiber Responses using Fiber-Specific Modeling.

Journal of neurophysiology·2026
Same journal

HCN channels modulate the medium afterhyperpolarization and adjust the firing gain of fast alpha motoneurons in mice.

Journal of neurophysiology·2026
Same journal

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.

Journal of neurophysiology·2026
Same journal

When "Noise" Isn't Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS).

Journal of neurophysiology·2026
Same journal

Abrupt Scene Onsets and Gradually Emerging Scene Information Produce Distinct EEG Decoding Dynamics.

Journal of neurophysiology·2026
Same journal

From discovery to translation: charting a course for the <i>Journal of Neurophysiology</i>.

Journal of neurophysiology·2026
See all related articles

Sound conditioning protects the inner ear from damage by enhancing cochlear sensitivity and outer hair cell physiology. This study reveals mechanisms beyond the olivocochlear reflex, suggesting direct cellular changes offer noise protection.

Area of Science:

  • Auditory Neuroscience
  • Otoacoustic Emissions
  • Inner Ear Physiology

Background:

  • Chronic exposure to moderate sound levels (sound conditioning) can protect the inner ear from subsequent noise-induced damage.
  • Understanding the physiological mechanisms behind this protective effect is crucial for developing effective hearing loss prevention strategies.

Purpose of the Study:

  • To investigate the physiological changes induced by sound conditioning itself.
  • To determine how these changes contribute to protection against subsequent acoustic trauma.

Main Methods:

  • Guinea pigs were exposed to a moderate octave-band noise (85 dB SPL) daily for 6 hours.
  • Subsequent traumatic exposure (109 dB SPL) was assessed using compound action potentials (CAPs) and distortion product otoacoustic emissions (DPOAEs).

Related Experiment Videos

  • Cochlear sensitivity and olivocochlear (OC) reflex strength were evaluated post-conditioning.

    • Main Results:

    • Sound conditioning significantly reduced permanent threshold shifts (PTSs) and hair cell damage.
    • Enhanced cochlear sensitivity was observed in both CAPs and DPOAEs.
    • Conditioning strengthened both ipsilateral and contralateral OC reflex strength, but protection exceeded OC reflex amplification.

    Conclusions:

    • Sound conditioning induces physiological changes that protect the inner ear from acoustic trauma.
    • The protective effect is not solely explained by olivocochlear reflex enhancement.
    • Results suggest direct alterations in outer hair cell physiology are key to sound conditioning's protective benefits.