Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventilator-associated lung injury.

R M Kacmarek1

  • 1Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.

International Anesthesiology Clinics
|August 13, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EPISYNC study: predictors of patient-ventilator asynchrony in a prospective cohort of patients under invasive mechanical ventilation - study protocol.

BMJ open·2019
Same author

Continuous non-invasive cardiac output monitoring during exercise: validation of electrical cardiometry with Fick and thermodilution methods.

British journal of anaesthesia·2016
Same author

Is esophageal pressure monitoring essential for the most critically ill?

Minerva anestesiologica·2015
Same author

Efficacy of ventilation through a customized novel cuffed airway exchange catheter: a tracheal/lung model study.

British journal of anaesthesia·2014
Same author

It does not matter whether you are an elephant or a shrew: all mammals' tidal volumes are similarly scaled!

Minerva anestesiologica·2014
Same author

Management of refractory hypoxemia in ARDS.

Minerva anestesiologica·2013

Low lung volume protective ventilation (LPVS) may prevent lung injury and multi-organ dysfunction syndrome (MODS) in ARDS patients. Tailoring ventilation to individual lung mechanics is crucial for optimal outcomes.

Area of Science:

  • Critical Care Medicine
  • Pulmonary Physiology
  • Mechanical Ventilation

Background:

  • Mechanical ventilation can cause ventilator-induced lung injury (VILI) through overdistension.
  • Positive end-expiratory pressure (PEEP) can attenuate VILI.
  • Clinical data on low lung volume protective ventilation (LPVS) in ARDS is complex.

Purpose of the Study:

  • To evaluate the efficacy of LPVS in preventing VILI and its consequences.
  • To emphasize the importance of individualized ventilation strategies based on lung mechanics.
  • To advocate for the early use of higher PEEP and recruitment maneuvers in ARDS.

Main Methods:

  • Review of animal studies demonstrating VILI from overdistension.
  • Analysis of patient case series suggesting LPVS benefits.

Related Experiment Videos

  • Interpretation of randomized controlled trial data, including the Amato et al. trial.

    • Main Results:

    • LPVS attenuates VILI in animal models.
    • Individualized LPVS, guided by lung mechanics, appears prudent.
    • High peak alveolar pressure is recognized as detrimental; higher PEEP and recruitment maneuvers are beneficial in ARDS.

    Conclusions:

    • LPVS may prevent or reduce the severity of VILI.
    • Implementing LPVS can potentially prevent or attenuate multi-organ dysfunction syndrome (MODS).
    • Clinicians should consider individualized LPVS, higher PEEP, and recruitment maneuvers for ARDS management.