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Capillary electrophoresis enantioseparation of drugs using beta-cyclodextrin polymer: intramolecular synergistic
1School of Materials Sciences and Chemical Engineering, Beijing Institute of Technology, PR China.
Electrophoresis
|August 13, 1999
Abstract:
Enantiomers of eight basic compounds of pharmaceutical interest were studied by capillary electrophoresis (CE) using a soluble cyclodextrin (CD) polymer and native CD as chiral selectors. The effects of the polymer concentration and the pH of the buffer solution on resolution were examined. It was found that the beta-CD polymer shows higher stereoselectivity than its parent cyclodextrin. Such improvement is due to the structural difference between beta-CD and beta-CD polymer. These results suggested the existence of an intramolecular synergistic effect in CE.