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Related Experiment Videos

Liver abnormalities in Turner syndrome.

M Salerno1, S Di Maio, N Gasparini

  • 1Dipartimento di Pediatria, Università Federico II, Napoli, Italy.

European Journal of Pediatrics
|August 13, 1999
PubMed
Summary
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Hepatic abnormalities occur in 20% of girls with Turner syndrome (TS), often linked to hormonal therapies like oestrogens or oxandrolone. Regular liver function monitoring is crucial for managing TS patients.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Hepatology

Background:

  • Turner syndrome (TS) is a genetic condition affecting girls.
  • Hepatic abnormalities are not fully understood in TS patients.
  • The role of hormonal therapies in TS-related liver issues requires investigation.

Purpose of the Study:

  • To determine if hepatic abnormalities are characteristic of Turner syndrome.
  • To assess the influence of hormonal therapies and other factors on liver function in TS.
  • To evaluate the frequency and causes of liver enzyme elevation in girls with TS.

Main Methods:

  • Longitudinal monitoring of liver enzymes (ALT, AST, GGT) in 70 TS patients over a mean of 7.6 years.
  • Analysis of enzyme levels before and during hormonal therapy.

Related Experiment Videos

  • Categorization of liver abnormalities based on potential causes (drug-related, autoimmune, cryptogenic).

    • Main Results:

    • 20% of TS patients (14/70) showed elevated liver enzymes, typically after age 7.
    • Hepatotoxicity was more common with oestrogens or oxandrolone than growth hormone.
    • Drug-related causes were most frequent (10/14), with some cases requiring treatment cessation.

    Conclusions:

    • Hepatic abnormalities are relatively common in Turner syndrome.
    • Liver function surveillance is recommended for all TS patients, regardless of hormonal treatment.
    • Causes can be drug-induced, autoimmune, or cryptogenic, often with a benign course.