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Related Experiment Videos

Bone mineralisation in ex-preterm infants aged 8 years.

L S Bowden1, C J Jones, S W Ryan

  • 1Neonatal Unit, Liverpool Women's Hospital, UK.

European Journal of Pediatrics
|August 13, 1999
PubMed
Summary

Ex preterm infants show reduced bone mineral mass and hip bone density at age 8. While bone mineral content adjusted for size was similar, hip bone mineral density remained lower, indicating long-term skeletal deficits.

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Area of Science:

  • Pediatric Bone Health
  • Neonatal Medicine
  • Skeletal Development

Background:

  • Perinatal mineral deficits are common in preterm infants.
  • Limited data exists on long-term bone mineralization in this population.
  • Understanding skeletal outcomes is crucial for preterm infant follow-up.

Purpose of the Study:

  • To assess long-term bone mineral content (BMC) and bone mineral density (BMD).
  • To compare skeletal outcomes in ex-preterm infants (<32 weeks gestation) with controls at 8 years of age.
  • To identify factors associated with bone mineralization deficits.

Main Methods:

  • Dual-energy X-ray absorptiometry (Hologic QDR 1000) used to measure BMC and BMD.
  • Measurements taken at lumbar spine, forearm, and hip in 46 ex-preterm infants and controls.
  • Height, weight, and fracture history were recorded.

Main Results:

  • Ex-preterm infants were shorter and lighter than controls.
  • Unadjusted BMC was lower in preterm infants, but normalized for height and weight.
  • BMD was significantly reduced in the hip of the preterm group.
  • Prolonged ventilation correlated with lower BMC; preterm formula feeding duration correlated with higher BMC.
  • Accidental fractures were less common in ex-preterm infants.

Conclusions:

  • Ex-preterm infants exhibit reduced bone mineral mass relative to their growth.
  • Significant reduction in hip bone mineral density persists at 8 years of age.
  • Long-term skeletal monitoring is important for individuals born preterm.

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