Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNAPROBE, a computer program which generates oligonucleotide probes from protein alignments.

M Drummond1, J Stamper

  • 1Nitrogen Fixation Laboratory, John Innes Institute, Colney Lane, Norwich NR4 7UH, UK. martin.drummond@bbsrc.ac.ui

Nucleic Acids Research
|August 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between T90 and systemic hypertension in patients with obstructive sleep apnea: Data from the European sleep apnea database.

European journal of internal medicine·2026
Same author

Prevalence of Mycobacterium leprae and Mycobacterium lepromatosis in roadkill armadillos in Brazil.

Acta tropica·2024
Same author

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of <i>DYRK1A</i>.

bioRxiv : the preprint server for biology·2023
Same author

Hypofractionated or Conventionally Fractionated Adjuvant Radiotherapy After Regional Lymph Node Dissection for High-Risk Stage III Melanoma.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Teleconsultation in respiratory medicine - A position paper of the Portuguese Pulmonology Society.

Pulmonology·2022
Same author

Diagnostic and therapeutic approach of central sleep apnea in heart failure - the role of adaptive servo-ventilation. A statement of the Portuguese society of pulmonology and the Portuguese sleep association.

Pulmonology·2022
Same journal

Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8.

Nucleic acids research·2026
Same journal

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Nucleic acids research·2026
Same journal

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain.

Nucleic acids research·2026
Same journal

Enhancing the performance and interpretability of epigenetic clocks.

Nucleic acids research·2026
Same journal

FABIAN-variant 2026: improved prediction of the effects of DNA variants on transcription factor binding.

Nucleic acids research·2026
Same journal

Structural and biochemical characterization of Grimontia hollisae thermostable direct hemolysin with DNA reveals first Vibrio hemolysin with nuclease activity.

Nucleic acids research·2026
See all related articles

This study introduces a program for designing oligonucleotide probes using protein alignments and codon usage. The tool allows sequence weighting to improve specificity and bias results towards desired taxa.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Oligonucleotide probes are crucial for molecular biology techniques.
  • Designing effective probes requires considering protein alignments and organism-specific codon usage.

Purpose of the Study:

  • To present a computational program that aids in the design of oligonucleotide probes.
  • To incorporate protein sequence data and codon bias for improved probe design.

Main Methods:

  • The program utilizes protein sequence alignments as input.
  • It analyzes the codon usage patterns of the target organism.
  • Sequence weighting can be applied to manage sequence similarity or bias results.

Main Results:

Related Experiment Videos

  • The developed program facilitates the rational design of oligonucleotide probes.
  • It offers flexibility in handling sequence data for specific applications.

    • Conclusions:

    • This program provides a valuable tool for researchers needing to design specific oligonucleotide probes.
    • The integration of protein alignments and codon usage enhances probe design accuracy.