Related Experiment Videos
[Glucotoxicity and lipotoxicity, two implicated accomplices in the vicious circle of type 2 diabetes]
A J Scheen1, N Paquot, P J Lefèbvre
1Département de Médecine, CHU Sart Tilman, Liège.
Revue Medicale De Liege
|August 14, 1999
Abstract:
Type 2 diabetes mellitus is a dynamic disease whose natural history is characterized by a progressive aggravation leading to a progressively severe hyperglycaemia, which generally requires a more complex therapy as time progresses. Such an evolution results from a vicious circle where both glucotoxicity and lipotoxicity contribute to reduce insulin secretion and the action of insulin on cell glucose metabolism. These new concepts are able to modify the strategies of prevention and treatment of type 2 diabetes.