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Updated: Jul 26, 2026
14:54
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Acinetobacter junii causes life-threatening sepsis in preterm infants
A J de Beaufort1, A T Bernards, L Dijkshoorn
1Department of Paediatrics, Leiden University Medical Center, The Netherlands. Adbeaufort@kindjc.azl.nl
Acta Paediatrica (Oslo, Norway : 1992)
|August 14, 1999
Summary
Acinetobacter junii caused sepsis in preterm infants. Contaminated intravenous fat emulsion was the likely source, highlighting the need for aseptic preparation of neonatal nutrition.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Acinetobacter junii outbreaks can occur in neonatal intensive care units.
- Preterm infants are particularly vulnerable to severe infections.
Purpose of the Study:
- To investigate a sudden outbreak of Acinetobacter junii sepsis in preterm infants.
- To identify the source and risk factors associated with the infection.
Main Methods:
- Clinical case review of six affected preterm infants.
- Microbiological analysis of blood cultures.
- In vitro susceptibility testing of Acinetobacter junii to various intravenous nutritional products.
Main Results:
- Six preterm infants developed Acinetobacter junii sepsis within 48 hours.
- Intravenous fat emulsion (Intralipid 10%) supported excellent growth of the outbreak strain.
- Other nutritional solutions did not support significant growth, and no common batch contamination was identified.
Conclusions:
- Acinetobacter junii can cause life-threatening sepsis in preterm neonates.
- Contaminated intravenous fat emulsion is a potential source of infection.
- Aseptic preparation of intravenous feedings is crucial for infection control in neonatal units.
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