Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human parathymic lymph node: morphological and functional significance.

A Tanegashima1, A Yamashita, H Yamamoto

  • 1Department of Forensic Medicine and Sciences, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan.

Immunology
|August 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial Insulin Resistance Exacerbates Experimental Periodontitis.

Journal of dental research·2023
Same author

Characterization of Carotid Plaque Components by Quantitative Susceptibility Mapping.

AJNR. American journal of neuroradiology·2019
Same author

Fifteen-year survival of resin-bonded vs full-coverage fixed dental prostheses.

Journal of prosthodontic research·2019
Same author

Incidence of respiratory depression after epidural administration of morphine for cesarean delivery: findings using a continuous respiratory rate monitoring system.

International journal of obstetric anesthesia·2018
Same author

Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia.

Osteoarthritis and cartilage·2018
Same author

P450 oxidoreductase deficiency with maternal virilization during pregnancy.

Clinical and experimental obstetrics & gynecology·2018

Parathymic lymph nodes (PTLNs) were identified in children, located on the thymus. These unique lymph nodes exhibit distinct cellular compositions, suggesting a role in T cell differentiation.

Area of Science:

  • Immunology
  • Anatomy
  • Pediatrics

Background:

  • Parathymic lymph nodes (PTLNs) are lymphatic organs found on or between thymus lobes.
  • Previously documented only once in human fetal material 90 years ago.
  • Their presence and characteristics in children have not been previously reported.

Purpose of the Study:

  • To report the occurrence of parathymic lymph nodes (PTLNs) in children.
  • To describe the histological and cellular characteristics of human PTLNs.
  • To investigate the potential role of PTLNs in T cell differentiation.

Main Methods:

  • Identification and anatomical description of PTLNs in children.
  • Histological examination of PTLN structure, including medullary cords, cortex, follicles, and high endothelial venules (HEV).

Related Experiment Videos

  • Flow cytometric analysis to determine T:B cell and CD4+:CD8+ T cell ratios in PTLNs compared to other lymphoid tissues and peripheral blood.

    • Main Results:

    • Human PTLNs were identified as small, encapsulated organs on the thymus surface or between lobes.
    • Histology revealed thin medullary cords with few plasma cells, a well-developed paracortical area with HEVs, and a thin cortex with undeveloped follicles.
    • Flow cytometry showed significantly higher T:B cell (14.6+/-9.3) and CD4+:CD8+ T cell (4.9+/-1.4) ratios in PTLNs compared to other tissues and blood.

    Conclusions:

    • Human parathymic lymph nodes (PTLNs) are distinct lymphoid organs present in children.
    • The unique histological and cellular composition of PTLNs, particularly the high T cell ratios, differs from peripheral lymphoid tissues.
    • These characteristics suggest that human PTLNs may play a role in the functional differentiation of T cells.