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Updated: Jul 18, 2026
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Prognostic significance of p53 codon 72 polymorphism in lung carcinomas
1Institute of Toxicology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
European Journal of Cancer (Oxford, England : 1990)
|August 17, 1999
Summary
The p53 codon 72 polymorphism may influence lung cancer prognosis. Specifically, the Pro/Pro genotype was linked to poorer outcomes in certain lung cancer patient subgroups, including males and those with squamous cell carcinoma.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Lung cancer is a leading cause of cancer mortality in Taiwan.
- Identifying molecular markers for cancer susceptibility and prognosis is crucial.
- The p53 pathway plays a significant role in tumorigenesis.
Purpose of the Study:
- To investigate the association between p53 codon 72 polymorphism and lung cancer prognosis.
- To identify potential prognostic value of specific p53 genotypes in lung cancer patients.
Main Methods:
- Genotyping analysis of p53 codon 72 polymorphism.
- Survival analysis in 114 lung cancer patients.
- Subgroup analysis based on cancer type, sex, age, and stage.
Main Results:
- Median survival times varied by genotype: Pro/Pro (25 months), Arg/Arg (26 months), Arg/Pro (36 months).
- The Pro/Pro genotype was associated with a worse prognosis compared to Arg/Pro, particularly in squamous cell lung cancer, males, and individuals aged 60-69.
- Early-stage lung cancer patients with Pro/Pro and Arg/Arg genotypes showed a trend towards worse prognosis than those with Arg/Pro.
Conclusions:
- p53 codon 72 polymorphism may serve as a prognostic factor in specific lung cancer patient subgroups.
- Further research is warranted to validate these findings and explore therapeutic implications.
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