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Predictive factors for node involvement in papillary thyroid carcinoma. Univariate and multivariate analyses.
1Clinique Chirurgicale 1, CHU Nantes, France.
European Journal of Cancer (Oxford, England : 1990)
|August 17, 1999
Summary
Identifying papillary thyroid carcinoma patients who need lymph node dissection is crucial. Absence of a tumor capsule and perithyroid involvement are key predictors of lymph node metastasis, guiding surgical decisions.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Papillary thyroid carcinoma frequently involves lymph nodes, necessitating neck dissection.
- Neck dissection can lead to significant patient morbidity.
Purpose of the Study:
- To identify intraoperative criteria predicting lymph node metastasis in papillary thyroid carcinoma.
- To refine indications for lymph node dissection, minimizing patient morbidity.
Main Methods:
- Retrospective analysis of 158 papillary thyroid carcinoma patients treated between 1974 and 1996.
- Evaluation of clinical and pathological factors for predicting lymph node involvement, including tumor capsule status and perithyroid invasion.
Main Results:
- 63% of patients had lymph node involvement.
- Absence of a tumor capsule and perithyroid involvement were significant predictors in multivariate analysis.
- Risk of node involvement was 38.3% without these factors and 87.1% with both.
Conclusions:
- Absence of a tumor capsule and perithyroid involvement are critical factors in determining lymph node metastasis risk.
- These criteria can guide decisions regarding the necessity of lymph node dissection in papillary thyroid carcinoma patients.