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Related Experiment Videos

Experience with invasive Candida infections.

H Girishkumar1, A M Yousuf, J Chivate

  • 1Department of Surgery, Bronx-Lebanon Hospital Center, NY 10457, USA.

Postgraduate Medical Journal
|August 17, 1999
PubMed
Summary
This summary is machine-generated.

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Invasive fungal infections, primarily Candida albicans, led to a 70% mortality rate in a 1995 Bronx study. Risk factors included concurrent bacteremia and broad-spectrum antibiotic use.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Clinical Microbiology

Background:

  • Fungal infections pose a significant threat in hospital settings.
  • Candida species are common causes of invasive fungal disease.
  • Understanding risk factors and outcomes is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence, characteristics, and mortality of invasive fungal infections.
  • To identify risk factors associated with increased mortality.
  • To analyze the clinical presentation and outcomes of patients with positive fungal cultures.

Main Methods:

  • Retrospective analysis of 227 patients with positive fungal cultures from January to July 1995.
  • Focus on 43 patients with invasive fungal disease (fungus-positive blood cultures).

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  • Data collection on patient demographics, clinical symptoms, comorbidities, treatments, and outcomes.

    • Main Results:

    • Candida species were the most common isolates, with Candida albicans causing 49% of fungemia.
    • The overall mortality rate for invasive fungal infection was 70% (30 deaths).
    • Higher mortality was observed in patients with concurrent bacteremia, broad-spectrum antibiotic use, HIV infection, central venous catheter, and organ failure.

    Conclusions:

    • Invasive fungal infections, particularly candidemia, are associated with high mortality.
    • Prompt identification and management of risk factors are essential.
    • Further research into preventative strategies and targeted therapies is warranted.