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Transgenic models of growth hormone action
J J Kopchick1, L L Bellush, K T Coschigano
1Edison Biotechnology Institute, Konneker Research Laboratories, College of Osteopathic Medicine, Ohio University, Athens 45701, USA. jkopchick1@ohiou.edu
Annual Review of Nutrition
|August 17, 1999
Summary
Researchers explored the molecular mechanisms of growth hormone (GH) action and utilized GH transgenic mice models. This review highlights GH
Area of Science:
- Endocrinology and Molecular Biology
- Biochemistry and Physiology
Background:
- Growth hormone (GH) discovery in 1921 and bovine GH isolation in 1944.
- Ongoing research into the structure-activity and structure-metabolic activity relationships of GH.
- GH's crucial role in growth promotion and metabolic regulation.
Purpose of the Study:
- To review the current understanding of the molecular mechanisms underlying GH action.
- To describe various GH transgenic mouse models used in research.
- To identify potential nutritional research targets related to GH activity.
Main Methods:
- Literature review of GH action mechanisms.
- Analysis of studies employing GH transgenic mouse models.
- Synthesis of findings on GH structure-function relationships.
Main Results:
- Summary of established molecular pathways of GH signaling.
- Overview of insights gained from GH transgenic mouse studies.
- Identification of specific areas for future nutritional interventions.
Conclusions:
- GH action involves complex molecular signaling pathways.
- Transgenic mouse models provide valuable insights into GH function.
- Understanding GH structure-activity relationships can guide nutritional strategies.